I just got my annual bonus from work, and my IRS/CA refunds as well. I'm feeling kind of flush, but I've found that the best way to keep money from burning a hole in my pocket is to give some of it away. In the past I've donated to a few charities like AmFAR, Project Open Hand, and Larkin St. I've also sponsored friends doing the AIDS Ride or LifeCycle.
I spent a few lean years recovering from my own personal dot-bomb and didn't have a lot of money to donate, but now I am in good enough shape that I feel I should get back in the habit. But I need some new causes. I don't pretend like I'm plugged in enough to know what all the good organizations or causes are, so why don't you all tell me what your favorite ones are and I'll see if I can find some good ones there. Also, if anyone is doing the LifeCycle or AIDS Walk or whatever this year, I'm a good person to hit up.